We explored how iron influences food poisoning, particularly in the context of campylobacteriosis, a common foodborne illness. Our focus was on the effects of deferoxamine (DESF), an iron-chelating compound, when administered orally to mice before they were infected.
In our study, we included microbiota-depleted IL-10 mice that received DESF through their drinking water starting a week ahead of being exposed to the Campylobacter strain known as 81-176. While we did not observe any significant reduction in the levels of the bacteria in the gastrointestinal tract, we did identify some noteworthy improvements in the overall health status of the infected mice by the sixth day post-infection.
These findings suggested that DESF treatment seemed to alleviate the disease's impact, manifesting as reduced cell death in the colon, lower numbers of immune cells like neutrophils accumulating in the large intestines, and decreased levels of inflammatory markers, including IFN-γ and MCP-1, in both the intestines and systemically.
Overall, our research illustrates the potential for iron-targeting strategies to positively affect the progression and severity of campylobacteriosis, offering a new outlook for treatment approaches when conventional antibiotic methods are not recommended.
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Most Useful Reviews
10
Improved condition
163 people found this helpful
This is a very cool find! After starting on supplemental iron, my ferritin levels rose from 40 to 70, significantly alleviating my lethargy and constant fatigue. My hair loss has also reduced. I took one capsule daily with food for two months, and I definitely recommend it! Let me know if you find my review helpful.
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10
Ferritin increase
47 people found this helpful
My ferritin increased from 30.4 to 53.8 after three months of taking 60 capsules, despite often missing doses. I followed a strict regimen of taking it with Vitamin C and avoided tea and coffee that can interfere with iron absorption. As I don't eat meat, this result is excellent for me, and I highly recommend it! Please like if you agree.
We explored how iron influences food poisoning, particularly in the context of campylobacteriosis, a common foodborne illness. Our focus was on the effects of deferoxamine (DESF), an iron-chelating compound, when administered orally to mice before they were infected.
In our study, we included microbiota-depleted IL-10 mice that received DESF through their drinking water starting a week ahead of being exposed to the Campylobacter strain known as 81-176. While we did not observe any significant reduction in the levels of the bacteria in the gastrointestinal tract, we did identify some noteworthy improvements in the overall health status of the infected mice by the sixth day post-infection.
These findings suggested that DESF treatment seemed to alleviate the disease's impact, manifesting as reduced cell death in the colon, lower numbers of immune cells like neutrophils accumulating in the large intestines, and decreased levels of inflammatory markers, including IFN-γ and MCP-1, in both the intestines and systemically.
Overall, our research illustrates the potential for iron-targeting strategies to positively affect the progression and severity of campylobacteriosis, offering a new outlook for treatment approaches when conventional antibiotic methods are not recommended.
Read More
User Reviews
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10
Improved condition
163 people found this helpful
This is a very cool find! After starting on supplemental iron, my ferritin levels rose from 40 to 70, significantly alleviating my lethargy and constant fatigue. My hair loss has also reduced. I took one capsule daily with food for two months, and I definitely recommend it! Let me know if you find my review helpful.
Read More
10
Ferritin increase
47 people found this helpful
My ferritin increased from 30.4 to 53.8 after three months of taking 60 capsules, despite often missing doses. I followed a strict regimen of taking it with Vitamin C and avoided tea and coffee that can interfere with iron absorption. As I don't eat meat, this result is excellent for me, and I highly recommend it! Please like if you agree.
Read More
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References
Bereswill S, Mousavi S, Weschka D, Buczkowski A, Schmidt S, et al. Iron Deprivation by Oral Deferoxamine Application Alleviates Acute Campylobacteriosis in a Clinical Murine Infection Model. Biomolecules. 2022;13. 10.3390/biom13010071